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Memory
Research from Johns Hopkins University suggests that a dose of caffeine after a learning session may help boost long-term memory.
It has been suggested that caffeine enemas may help prepare the colon for an endoscopy or colonoscopy by supporting the excretion of bile through the colon wall.
Proponents claim that a caffeine enema increases the levels of glutathione, an antioxidant, and so it supports the natural processes of detoxification in the liver.
However, there is little evidence to support this theory.
Coffee consumption may help decrease the risk of cirrhosis and slow the rate of disease progression in hepatitis C infection. Observational studies have found that coffee may have protective benefits for people with hepatocellular cancer.
Long-Term Side Effects of Caffeine
Caffeine use or overuse may also have some long-term side effects. These can include:
Caffeine Dependence
Caffeine Withdrawal
Another common long-term side effect is the experience of caffeine withdrawal symptoms. People who consume large amounts of caffeine more frequently may be more likely to feel withdrawal symptoms after several hours without a dose of caffeine.
Symptoms of caffeine withdrawal can include:
- Low mood
- Headache
- Nausea
- Mental fogginess
- Lightheadedness
Research has found that people who consume caffeine daily have a higher risk of experiencing withdrawal symptoms such as fatigue and headaches.
Caffeine During Pregnancy
Excessive caffeine consumption during pregnancy may lead to adverse side effects. Research suggests that the risk of miscarriage increased by 14% for each 100 mg consumed per day. Some research suggests that caffeine use during pregnancy may contribute to low birth weight.
Mixing alcohol and energy drinks
When alcoholic beverages are mixed with energy drinks, the caffeine can mask the depressant effects of alcohol. Alcohol also decreases the metabolism of caffeine, prolonging its effects.
Drinkers who consume alcohol mixed with energy drinks are three times more likely to binge drink than drinkers who do not report mixing alcohol with energy drinks.
A person is unlikely to die from consuming too much caffeine in the diet. It is estimated that it would take 149 or so cans of caffeinated energy drink to kill an average adult male. Vomiting would most certainly occur before a person had a chance to consume a fatal overdose of caffeine from dietary sources.
Share on Pinterest Caffeine pills are popular with young people, but they can be hazardous.However, pure caffeine is a powerful stimulant, and very small amounts can lead to an accidental overdose. A single teaspoon of pure caffeine is roughly equivalent to 28 cups of coffee.
In addition to the usual adverse effects from too much caffeine, high doses can lead to:
- anxiety
- heart palpitations and rapid heart beat
- sweating
- nausea and vomiting
- cardiac arrest
Whether consumed as a food or a medicine, the blood and body tissues absorb caffeine within around 45 minutes. It reaches peak level in the blood within 1 hour and remains there for 4 to 6 hours.
While there, caffeine changes the way the brain and body work.
Caffeine has a similar structure to adenosine, a chemical that is present in all human cells.
In the brain, adenosine acts as a CNS depressant.
Adenosine promotes sleep and suppresses arousal by slowing down nerve activity. Adenosine binding also causes blood vessels in the brain to dilate, to increase oxygen intake during sleep. When awake, the levels of adenosine in the brain rise each hour, making the brain and the body less alert.
Natural sources of caffeine may contain fewer harmful compounds
Another consideration is that foods containing synthetic caffeine often contain other compounds that you generally shouldn’t have too much of.
For instance, regular soda contains large amounts of processed sugar, which has been linked to a variety of negative health outcomes, including obesity, type 2 diabetes, and heart disease ( 11 ).
Energy drinks contain various nonnutritive stimulants, such as taurine, L-carnitine, D-glucuronolactone, and inositol. The long-term effects of ingesting these are still unknown ( 12 ).
SummaryNatural caffeine and synthetic caffeine have very similar effects on your body. However, foods that contain natural sources of caffeine are often more nutritious and less likely to contain harmful compounds.
How is natural caffeine different from synthetic caffeine?
Unlike natural caffeine, which comes from foods found in nature, synthetic caffeine is produced in a lab. It’s commonly added to packaged foods and beverages such as soda, juice, chewing gum, candy, and energy drinks.
Synthetic caffeine is also often added to non-food products such as pain relievers, makeup, face creams, and other cosmetics ( 2 , 3 ).
The Food and Drug Administration requires that caffeine be listed on food labels when it has been added during production. This is not required of foods that naturally contain caffeine, such as coffee or tea ( 5 ).
So if you see caffeine on a food or beverage’s label, that product most likely contains synthetic caffeine.
The chemical structure of synthetic caffeine is almost indistinguishable from that of natural caffeine.
Despite this, many claim that synthetic caffeine is absorbed much more quickly than natural caffeine, causing a peak in energy followed by a steep crash. However, there is very little scientific backing to this claim.
