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Adapalen na zmarszczki - Skuteczne leczenie i porady dotyczące pielęgnacji skóry
Identification
Adapalene is a third-generation topical retinoid with anti-comedogenic, comedolytic, and anti-inflammatory properties used to treat acne vulgaris in adolescents and adults.
Acne vulgaris is a multifactorial disorder of the pilosebaceous unit involving increased sebum production, inflammation, and hyperproliferation/hyperkeratinization of the follicular infundibulum. It is also associated with Cutibacterium acnes (also known as Propionibacterium acnes). Adapalene is a third-generation topical retinoid used for the treatment of acne vulgaris. 4 Adapalene has similar efficacy but a superior safety profile compared to tretinoin. 5 Tazarotene is more efficacious than adapalene but is designated as pregnancy category X and hence is contraindicated in pregnant women. 4 Adapalene can also be combined with benzoyl peroxide (BPO), which possesses bactericidal properties 6 , and either adapalene alone, or adapalene BPO combination products, are commonly used to treat mild-to-severe acne. 4
Differin®, produced by Galderma Labs, was first granted FDA approval on May 31st, 1996, as a 0.1% adapalene topical solution. Differin was later made available as 0.1% gel, cream, or lotion, or 0.3% gel products. On December 8th, 2008, Galderma Labs gained FDA approval for Epiduo®, a 0.1% adapalene, 2.5% BPO combination gel. 8
Type Small Molecule Groups Approved Structure
Structure for Adapalene (DB00210)
- 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid
- Adapalene
- Adapalène
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Poor quality drug data slowinPharmacoeconomics
- Nycomed us inc
- Galderma laboratories lp
- Glenmark generics inc usa
- Pliva hrvatska doo
- Galderma research and development inc
- Galderma Laboratories
| Form | Route | Strength |
|---|---|---|
| Gel | Topical | |
| Cream | Cutaneous | 0.100 g |
| Gel | Cutaneous | 0.300 g |
| Cream | Topical | 0.1 g/100g |
| Cream | Topical | 1 mg/1g |
| Gel | Topical | 0.1 g/1g |
| Gel | Topical | 1 mg/1g |
| Gel | Topical | 45 g/1g |
| Lotion | Topical | .1 g/100mL |
| Gel | Topical | 0.00036 g/1g |
| Swab | Topical | 1 mg/1mL |
| Cream | Topical | |
| Gel | ||
| Gel | Topical | 0.100 g |
| Kit | Topical | |
| Gel | Cutaneous | 0.1 % w/w |
| Gel | Topical | 1.00 mg/g |
| Cream | Topical | 0.1 % |
| Gel | Topical | 0.1 % |
| Gel | Topical | 0.1 %w/w |
| Gel | Topical | 3 mg/1g |
| Liquid | Topical | 0.1 % |
| Lotion | Topical | 0.1 g/100mL |
| Lotion | Topical | 0.1 % |
| Lotion | Topical | 1 mg/1g |
| Solution | Topical | 1 mg/1mL |
| Gel | Topical | 1 mg/g |
| Cream | Cutaneous | 0.1 % |
| Gel | Topical | 0.3 % |
| Gel | Topical | |
| Gel | Cutaneous | |
| Gel | Topical | 0.10 % |
| Cream | ||
| Solution | Topical | |
| Gel | Cutaneous | 0.100 g |
| Gel | Cutaneous | 1.000 MG |
| Gel | Topical | 0.1 % W/W |
| Gel | Topical | 0.1 g/100g |
| Gel | Cutaneous | 0.1 % |
| Gel | Cutaneous | 110.000 mg |
| Cream | Topical | 0.3 g |
| Gel | Cutaneous | 0.100 g |
| Cream | Topical | |
| Cream | Topical | 0.1 g |
| Gel | Topical | 0.3 g |
| Gel | Topical | 0.1 g |
Adapalene - Uses, Side Effects, and More
Adapalene is commonly used to treat acne vulgaris on your skin.
Adapalene may also be used for other conditions as determined by your healthcare provider.
How does adapalene work (mechanism of action)?
Adapalene changes how your skin cells grow and shed so they do not clog pores or form acne. It also helps decrease redness and swelling that happens with acne.
How is adapalene supplied (dosage forms)?
Adapalene is available as Differin and generic adapalene in the following dosage forms that are applied to the skin.
- 0.1% topical cream
- 0.1% topical gel
- 0.3% topical gel
- 0.1% topical lotion
- 0.1% topical solution
How should I store adapalene?
Topical Cream, Gel, and Solution. Adapalene cream, gel, and solution should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). They can be exposed to temperatures between 59 F to 86 F (15 C to 30 C), for shorter periods of time, such as when transporting them. Store in a cool, dry place, in a tightly closed container. Do not freeze.
Topical Lotion. Adapalene lotion should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C), for shorter periods of time, such as when transporting it. Store in a cool, dry place, in a tightly closed container. Do not freeze or refrigerate. Protect from heat and light.