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Wyprysk z hiperkeratozą - Objawy, Diagnoza i Leczenie
Introduction
Hyperkeratosis refers to the increased thickness of the stratum corneum, the outer layer of the skin. Stratum corneum is composed of multiple layers of keratinocyte bodies that, during maturation, produced keratin and subsequently have lost their nucleus and cytoplasmic organelles. The result is a basketweave appearance of anucleate keratinocytes that protect the underlying cells during maturation.
Hyperkeratosis is subclassified as orthokeratotic or parakeratotic. Orthokeratotic hyperkeratosis refers to the thickening of the keratin layer with preserved keratinocyte maturation, while parakeratotic hyperkeratosis shows retained nuclei as a sign of delayed maturation of keratinocytes. Hyperkeratosis can be associated with dyskeratosis. It represents a premature (keratinocytes that are located below the granular cell layer) or abnormal keratinization of individual keratinocytes.
Hyperkeratosis, associated with other abnormalities in the skin biopsy, can be a key to the final histological diagnosis. Epidermal hypertrophy is a benign alteration of the skin that presents with acanthosis (increased thickness of the keratinocyte layers) and hyperkeratosis.
A Word From Verywell
A skin condition can be challenging to deal with, especially if it causes painful symptoms. The good news is that dealing with most forms of hyperkeratosis is manageable with the proper treatment. In most cases, this condition is not severe or life-threatening.
The best thing you can do if you have hyperkeratosis is to speak to a dermatologist (a medical doctor specializing in conditions of the skin, hair, and nails) about your condition and any concerns you have. They will be able to determine the next steps to address your condition.
Frequently Asked Questions
The treatment for hyperkeratosis will depend entirely on its type and the underlying cause. Treatment isn't always necessary because some forms of hyperkeratosis are either asymptomatic or present with mild cosmetic symptoms. The most common forms of treatment include keratolytics, moisturizers, emollients, and retinoids.
Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.
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By Angelica Bottaro
Bottaro has a Bachelor of Science in Psychology and an Advanced Diploma in Journalism. She is based in Canada.
Fabiola Farci , Gauri D. Mahabal .
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Last Update: September 4, 2023 .
Hyperkeratosis refers to the increased thickness of the stratum corneum, the outer layer of the skin. It is most frequently due to chronic physical or chemical damage such as friction or the use of aggressive soaps but can also derive from chronic inflammation or a side-effect of different drugs, including chemotherapy. This activity reviews the evaluation and treatment of hyperkeratosis and highlights the role of the interprofessional team in evaluating and treating patients with this condition.
Summarize the major histologic forms of hyperkeratosis. Review the different pathologies that can manifest with hyperkeratosis.Explain the importance of collaboration and communication amongst the interprofessional team to ensure the appropriate diagnosis and treatment is selected for patients with hyperkeratosis.