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"Elosone - skuteczne rozwiązanie na trądzik"
Elosone – skutki uboczne
Każdy produkt leczniczy niesie ze sobą ryzyko wystąpienia różnorodnych skutków ubocznych, chociaż nie każdy pacjent ich doświadczy. U pacjentów stosujących Elosone działania niepożądane występują z różną częstotliwością.
Bardzo rzadko (u mniej niż 1 na 10000 osób):
- zapalenie mieszków włosowych,
- uczucie pieczenia,
- świąd.
Częstość nieznana:
- kontaktowe zapalenie skóry,
- niedobór melaniny,
- nadmierne owłosienie,
- rozstępy,
- zmiany trądzikopodobne,
- zanik skóry,
- zakażenia, czyraki,
- zaburzenia czucia,
- ból w miejscu podania,
- reakcje w miejscu podania,
- nieostre widzenie.
Lista rzadziej występujących skutków ubocznych znajduje się w ulotce leku.
Furoinian mometazonu może wchłaniać się do organizmu i wywoływać ogólnoustrojowe skutki uboczne, takie jak: odwracalne zahamowanie czynności osi podwzgórze-przysadka-nadnercza, zespół Cushinga, podwyższony poziom glukozy we krwi oraz wydalanie cukru z moczem. Do objawów zespołu Cushinga należą: otyłość, twarz „księżycowata”, zaczerwienienie twarzy, rozstępy, osłabienie, spadek odporności, wzrost ciśnienia tętniczego. Ryzyko wystąpienia działań niepożądanych jest wyższe w przypadku stosowania leku na duże powierzchnie uszkodzonej skóry, na fałdy skórne lub pod opatrunkiem.
U dzieci ryzyko wystąpienia ogólnoustrojowych skutków ubocznych jest wyższe. Lek może zaburzać wzrost i rozwój.
Store Elosone HT cream in the original container in a clean and dry place, protected from moisture, sunlight and heat.
Elosone HT cream is used to help treat melasma/hyperpigmentation of the skin. It also helps lighten skin tone or appearance and dark spots or age spots in older people due to exposure to the sun. Do n ot use this cream for any condition other than that specified by your doctor. .
This medicine is meant for external application and should not be swallowed. Do not apply to open wounds or weeping areas.
Do not use more than the recommended amount of this medicine, or do not use it for longer periods of time than directed.
Before starting Elosone HT cream, inform your doctor if you are pregnant, planning on becoming pregnant or breastfeeding. Also, inform your doctor about all other medicines that you are using.
Avoid exposure to sun rays after applying Elosone HT cream. Inform your doctor if you have a skin tumour or a family history of skin tumours.Elosone HT cream has no anti-acne or anti-pimple action and should not be used to treat such skin conditions.
Toxicity
Overdose with a mometasone furoate inhaler may occur with chronic overuse. Symptoms of chronic overuse may present as hypercorticism and adrenal suppression, and patients may not require any more treatment than monitoring.
In animal studies of pregnancy, some fetal toxic effects were seen at or above the maximum recommended human dose, though rodents are more sensitive to these effects than humans. The benefits and risks of use should be considered in pregnant patients
It is unknown if mometasone furoate is excreted in breast milk but other corticosteroids are and therefore caution should be exercised when administering to nursing mothers.
Safety and effectiveness in pediatric populations has been established through clinical trials, though there may be a reduction in expected growth of about 1cm per year depending on the dose and duration of treatment. Pediatric patients should be titrated to the lowest effective dose for mometasone furoate inhalers.
A trial of geriatric patients showed no difference in safety or efficacy compared to younger patients, however patients of an even greater age may still be more sensitive to mometasone furoate.
The use of a mometasone furoate inhaler in moderate or severe hepatic impairment rarely leads to detectable plasma concentrations though caution may be prudent with increasing degrees of severity.
The effects of mometasone furoate in renal impairment, and across gender and race have not been studied.
How Elosone works
In asthma, mometasone is believed to inhibit mast cells, eosinophils, basophils, and lymphocytes. There is also evidence of inhibition of histamine, leukotrienes, and cytokines.
Corticosteroids diffuse across cell membranes into the cytosol of cells where they bind to glucocorticoid receptors to produce their activity. Elosone has a particularly high receptor affinity compare to other corticosteroids, 22 times higher than that of dexamethasone. Elosone binding to a glucocorticoid receptor causes conformational changes in the receptor, separation from chaperones, and the receptor moves to the nucleus. Once at the nucleus, receptors dimerize and bind to a DNA sequence known as the glucocorticoid response element which either increases expression of anti-inflammatory molecules or inhibits expression of pro-inflammatory molecules (such as interleukins 4 and 5). Elosone also reduces inflammation by blocking transcription factors such as activator-protein-1 and nuclear factor kappa B (NF-kappaB).
