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Progesteron a pryszcze - Prawda czy mit?
Stoporex® Women – Balenie 5ks
Hladina závisí od veku aj fázy menštruačného cyklu:
- dievčatá vo veku od 0 do 9 rokov by mali mať do 2,59 nmol / l
- u žien je ho najmenej vo folukulárnej fáze, od 0,48 do 4,45 nmol / l
- počas ovulačnej fázy hladina stúpa k hodnotám 2,4 až 9,4 nmol / l
- najviac ho je v luteálnej fáze a to od 10,62 až do 89,14 nmol / l
- po skončení plodného obdobia klesá a to až do menopauzy
- počas nej klesá hodnota progesterónu na 0,67 až 2,32 nmol / l
- 30 až 40 krát viac hormónu sa produkuje počas tehotenstva
Množstvo hormónu v krvi kolíše aj v závislosti od toho, aké je obdobie dňa, nakoľko hormón sa uvoľňuje vo viacerých epizodických vrcholoch. Najviac ho je paradoxne počas odpočinku a spánku, najmenej ráno po zobudení. Variácia koncentrácie je aj 20 %. Hladina progesterónu dosahuje svoje úplné maximá na 5 až 7 deň cyklu po ovulácii.
Progestin side effects
Side effects of progestin use may include:
- Headaches
- Breast tenderness or pain
- Upset stomach, vomiting, diarrhea, and constipation
- Changes in appetite
- Weight gain
- Fluid retention
- Tiredness
- Muscle, joint, or bone pain
- Mood swings and irritability
- Excessive worrying
- Runny nose, sneezing, and cough
- Vaginal discharge
- Problems urinating
Uncommon but potentially serious side effects requiring medical attention include:
- Breast lumps
- Dimpling of breast skin
- Clear or bloody discharge from nipple
- Inverted nipple
- Crusting or scaling of the nipple
- Clay-colored stools
- Migraine headache
- Severe dizziness
- Slow speech or difficulty speaking
- Weakness or numbness of limbs
- Absence of coordination
- Breathlessness
- Pounding heartbeat
- Sharp chest pain
- Coughing up blood
- Leg swelling
- Loss of or blurred vision
- Bulging eyes
- Double vision
- Unexpected vaginal bleeding
- Uncontrollable shaking hands
- Seizures
- Stomach pain or swelling
- Depression
- Hives, skin rash, and itching
- Difficulty swallowing
- Swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
- Hoarseness
Progestins are not suitable for people with a history of the following conditions, unless they are using it to treat the condition:
- Liver tumors
- Genital cancer
- Breast cancer
- Severe arterial disease
- Undiagnosed vaginal bleeding
- Acute porphyrias
- Idiopathic jaundice
- Severe pruritus occurring during pregnancy
- Pemphigoid occurring during pregnancy
How we reviewed this article:
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http://project-aware.org/Managing/Hrt/progesterone.shtml - Estrogen and progestin (oral contraceptives). (2015, September 15)
https://medlineplus.gov/druginfo/meds/a601050.html - Guoyang, L., Morgan, T., Bahtiyar, M.O., Snegovskikh, V.V., Schatz, F., Kuczynski, E. . Norwitz, E.R. (2008, February). Single nucleotide polymorphisms in the human progesterone receptor gene and spontaneous preterm birth [abstract]. Reproductive Sciences
https://www.ncbi.nlm.nih.gov/pubmed/18276950 - Mayo Clinic Staff. (2015, April 14). Hormone therapy: Is it right for you? Retrieved from
http://www.mayoclinic.org/diseases-conditions/menopause/in-depth/hormone-therapy/art-20046372 - Menopause and hormones: common questions. (2015, September 28)
http://www.fda.gov/forconsumers/byaudience/forwomen/ucm118624.htm - Progesterone (2009, December 28). Encyclopaedia Britannica
http://www.britannica.com/EBchecked/topic/478202/progesterone - Progesterone. (2015, January 14)
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http://labtestsonline.org.uk/understanding/analytes/progesterone/tab/test/ - Sargis, R.M., (2015, August 4). An overview of the ovaries, estrogen, progesterone, and reproduction
http://www.endocrineweb.com/endocrinology/overview-ovaries - Spark, M.J. (2009, November 19). Progesterone or progestogen or progestin, which is it? The BMJ
http://www.bmj.com/rapid-response/2011/11/02/progesterone-or-progestogen-or-progestin-which-it - The testes glands. (n.d.)
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http://qlaira.com/en/consumer/your-cycle/role-of-hormones/index.php
High Progesterone Symptoms and Side Effects
High progesterone symptoms include breast swelling and tenderness, bloating, and other symptoms like anxiety, agitation, or depression. Your progesterone levels naturally rise during pregnancy and after ovulation, the release of an egg from the ovaries.
Conditions like ovarian cysts or a disorder of the adrenal glands can cause you to have too much progesterone. It can also be a sign of a molar pregnancy, where abnormal cells grow in the placenta.
This article discusses the symptoms of high progesterone and when to see a healthcare provider.
Kontroverze oko hormonske terapije
Početkom 2000-ih, ljudi su počeli da brinu o rizicima hormonske terapije. U to vreme, studija „Inicijative za zdravlje žena“ (WHI) pokazala je da postoji veza između kombinovane terapije estrogenom i progestinom i povećanog rizika od raka dojke i kardiovaskularnih bolesti.
Studija je takođe pokazala da je hormonska terapija više štetna za žene u postmenopauzi nego što je bila korisna, navodeći da je estrogen sam po sebi povezan sa povećanim rizikom od moždanog udara, kao i da nije od pomoći za bolest koronarne arterije.
WHI je objavio rezultate studije u „JAMA-i“, najavljujući da su, uprkos praćenju učesnika u proseku pet godina, istraživači studije prekinuli davanje estrogena plus progestina u studiji pre prvobitnog datuma prekida. Razlog za iznenadni kraj je to što se smatralo neetičkim nastaviti studiju, jer je otkriveno da je povećan rizik od raka dojke kod žena koje su uzimale lekove.
Zatim dve godine nakon ove objave, „WHI“ je takođe ranije prekinuo studiju samo o estrogenu, navodeći da je otkriven povećan rizik od pojave krvnih ugrušaka kod žena koje su uzimale lek. Međutim, ove žene se nisu suočile sa značajnim povećanjem rizika od raka dojke.
Uz to, aktuelnije analize ne pokazuju da su ovi rizici očigledni kod hormonske terapije. Uzmite u obzir naknadnu studiju objavljenu u septembru 2017. u „JAMA-i“, koja je objavila da ni estrogen plus progestin koji se uzimaju u proseku od 5,6 godina niti sam estrogen uzet u proseku od 7,2 godine nisu povezani sa povećanim rizikom od: smrti iz bilo kog uzroka, kardiovaskularnih problema ili raka tokom kumulativnog praćenja od 18 godina.
Iako postoje različita mišljenja o hormonskoj terapiji, vaš lekar vam može pomoći da utvrdi da li je to odgovarajući tretman za vas. Uvek je najbolje rešenje da se obratite stručnjaku u koga imate poverenje.
